What are the different histone modifications and what do the

What are the different histone modifications and what do they do?

Solution

Acetylation of lysine residues on histone proteins by histone acetyl transferases decreases DNA -Histone interaction and loosens the chromatin structure. This causes the transcription factors to bind and increase gene expression.

Phosphorylation of histones is highly dynamic, it takes place on serines, threonines and tyrosines, and controlled by kinases. - increase gene expression.

Histone methylation mainly occurs on the side chains of lysines and arginines. Does not alter the charge of the histone protein. Histone methyltransferases catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. - can induce expression or repress gene expression.