Explain the mechanism of Xchromosome dosage compensation in

Explain the mechanism of X-chromosome dosage compensation in mammals including the following terms in your answer: Barr body, Xist, lncRNA. What role does dosage compensation have in gene expression?

Solution

Genomic silencing by demethylation and X chromosome inactivation considered as the characteristic epigenetic processes may result in the cause of disease while they are not properly regulated in mammals.

Xist RNA is mainly generated from the inactivated X chromosome finally through methylation and deacetylation that affect the gene expression effectively in the phenotype due to barr body formation. Therefore, the mechanism of X-chromosome dosage compensation in mammals is essentially performed by the Xist or Xist lncRNA that do not code for a protein instead it is going to spread & coat the barr body so that the genes are not going to expressed. Therefore, it is essential to delete inactive Xist gene from chromatic to reinstate the mechanism of X-chromosome dosage compensation in mammals finally to eliminate barr body as part of dosage compensation