For amoxicillin resistance how do the physicochemical prope

For amoxicillin resistance , how do the physicochemical properties link to the ADME characteristics? Explain birefly and clearly for A, D, M , and E

Solution

ADME refers to the absorption, Distribution, Metabolism and Excretion.

Studying the ADME of the particular drug is very important to study pharmacokinetics. the drug which is taken should be absorbed by the intestinal villi and passes to the blood stream the absorption capacity is quite different from the group to group of drugs , route of adminstering, the drug is distributed into the various targets by the blood stream , thus it metabolise into the compounds by the redox metabolites through oxidation, later the excess Concentration will eliminated by the glomerular filtration of the kidneys which causes elimination through faeces and urine via kidneys.

AMOXICILLIN is the drug belong to the pencillinases, it will administered through IV, I\'m and orally, food won\'t interfere in the absorption of the amoxicillin, half-life of the amoxicillin is 61.3mins, it generally distributed very fast in the blood stream, excreted through kidneys. It is seen in the breast milk , can cross placenta so it effects the infant\'s either in foetal stage and nursing baby too. Long term adminstering cashing resistance to the amoxicillin antibiotic so that the metabolism will alters .