When admitted to the emergency room 21 savage was holding hi

When admitted to the emergency room, 21 savage was holding his right hand, which had a deep puncture hole in its palm He explained that he had fallen on a nail when exploring 22 Savage\'s barn. 21 Savage was given an anti-tetanus shot to prevent neural complications Tetanus bacteria fester in deep, dark wounds describe/illustrate how their toxins travel in neural tissue.

Solution

The tetanus toxin initially binds to peripheral nerve terminals. It is transported within the axon and across synaptic junctions until it reaches the central nervous system. There it becomes rapidly fixed to gangliosides at the presynaptic inhibitory motor nerve endings, and is taken up into the axon by endocytosis. The effect of the toxin is to block the release of inhibitory neurotransmitters glycine and gamma-aminobutyric acid (GABA) across the synaptic cleft, which is required to check the nervous impulse. If nervous impulses cannot be checked by normal inhibitory mechanisms, the generalized muscular spasms characteristic of tetanus are produced. The toxin appears to act by selective cleavage of a protein component of synaptic vesicles, synaptobrevin II, and this prevents the release of neurotransmitters by the cells.