Homework SourseA gene involved in neural development shows three times as m
| A gene involved in neural development shows three times as many synonymous site substitutions than nonsynonymous ones. A likely explanation is that this gene | |||||||||||
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| A gene involved in neural development shows three times as many synonymous site substitutions than nonsynonymous ones. A likely explanation is that this gene | |||||||||||
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Solution
-is under purifying selection
Synonymous substitutions are silent means the mutation which will not going to change encoded amino acid, whereas the non-synonymous substitutions are missense, here the mutation will change the encoded amino acid, it might be neutral or harmful or helpful to the species based on the outcome. Here the gene which is involved in neural developed is showing 3 times synonymous site substitution than nonsynonymous ones, this shows the gene is under purifying selection.
Ka/Ks ratio= No. of nonsynonymous substitutions per non-synonymous site (Ka)/No. of synonymous substitutions per synonymous site (Ks)
Less than 1 Ka/Ks ratio will indicate purifying selection.
