Describe 2 activities of Cyclin DCDK 46 complexes that ensur

Describe 2 activities of Cyclin D/CDK 4/6 complexes that ensures progression through the cell cycle.

Solution

The cyclin-cdks are master regulators of cell proliferation. These serine/threonine kinases are the motors that both start and stop the cell cycle in response to proliferative or antiproliferative signals. They phosphorylate substrates required to trigger orderly cell cycle progression, and thus their activity is tightly regulated in order to prevent inappropriate activation.