It has been found that many transcriptional regulators and r

It has been found that many transcriptional regulators and repressors are associated with histone acetyltransferases (add acetyl groups to histones) and deacetylases (remove acetyl groups from histones), respectively. In fact, some transcriptional coactivators are histone acetyltransferases themselves, such as TAFII250, a component of TFIID. What effect would inactivating TAFII250 have on transcription if it were the only component of the RNA Polymerase II complex responsible for nucleosome remodeling?

Solution

TAFII 250 :

1. It important role in expression of cell cycle control gene and regulate cell proliferation.

2. it is necessary for transcription of cyclin D and cyclin A

3. RNA Polymerase II transcription is the basal transcriptional factor IID , which is composed of TATA binding protein (TBP) and multiple TAF