The oxidation of fatty acids leads to the production of whic

The oxidation of fatty acids leads to the production of which of the following?

NADPH

CoASH

FAD

Acetyl CoA

More than one of the choices are listed

Solution

beta-oxidation is a process which is catabolic in nature, and occurs in cytosol of prokaryotes and mitochondria of eukaryotes, and generates Acetyl Coenzyme A or Acetyl-CoA. Each cycle of beta oxidation ends in production of one AcetylCoA.

Fatty acid synthesis and not beta oxidation uses NADPH ( Nicotinamide adenine dinucleotide phosphate.) along with Acetyl CoA to generate fatty acids. It is consumed during biosynthetic reactions and usually NADH is generated or produced. Generally formed in PPP or pentose phosphate pathway.

CoASH\' or \'HSCoA\' is a molecule of Acetyl coenzyme A without the acetyl group. It is called Coenzyme A. Fatty acid oxidation results in the formation of NAD, reduced flavin adenine dinucleotide or FADH₂ and acetyl-CoA. Only CoASH is not generated.

Electrons removed in the first step of fatty acid oxidation, FAD gets reduced to FADH₂ which is immediately converted to ATP. In mitochondria Fatty-acylCoA is acted upon by acyl-CoA dehydrogenase which is FAD-dependent.

Only Acetyl Co A along with NAD and FADH₂ are generated in fatty acid oxidation. Hence option d is the correct answer.