During the action potential which voltage sensitive channels

During the action potential, which voltage sensitive channels open first?

calcium

potassium

sodium

chloride

Solution

Sodium channel opens first. During resting membrane potential sodium ions are more extracellularly and potassium ions are more intracellular. During action potential, the sodium channel opens first and there is influx of sodium ions making more sodium channels to open. Now to maintain the resting membrane potential the potassium ions open.

Thus sodium channels are opened first followed by potassium channels..