If a mutation causes a decrease in the activity of histone a

If a mutation causes a decrease in the activity of histone acetyltransferases, histones will most likely have a _______ affinity for DNA, and there would be _______ in transcription rates.

reduced; a decrease

greater; an increase

greater; a decrease

reduced; no change

reduced; an increase

Solution

Explanation:

Histone acetyltraferases is very essential enzyme that regulates the DNA histones binding affinity and its play a key role in gene regulation. Histone acetyltraferases catalyse the acetylation reaction that neutralizes the positive charge of lysine. Therefore, decreases the affinity between DNA histone and DNA free from histone. This type of modification is very essential for transcription activation DNA repair etc.

From the given question, the enzyme acetyltransferases gene is mutated so that, reduce the enzyme activity. Hence, reduce the affinity of DNA and increase the transcription rate.

Answer: If a mutation causes a decrease in the activity of histone acetyltransferases, histones will most likely have a __ reduced _____ affinity for DNA, and there would be ___ an increase ____ in transcription rates.