For each of the following 3 conditions associated with arrhy

For each of the following 3 conditions associated with arrhythmias, explain (reason) the mechanism of arrhythmia you would expect (e.g. reentry, early after depolarization, etc) and the cellular cause (e.g. prolonged APD, slow conduction velocity, etc) given each pathophysiology shown (3 for each). Base your answer on information provided in class and the slides. The answer for the first is provided - you do the rest. Keep in mind that some causes may seem paradoxical. For example, a longer than normal APD and shorter than normal APD can cause an arrhythmia, but the mechanisms would be different. Ischemic Heart Disease Reduced I_Na. This will slow conduction velocity, which will reduce cardiac wavelength. When cardiac wavelength is reduced reentrant excitation is more likely to occur. Increase I_KATP. Increased acidosis.

Solution

b. Increases I,ATP: A delay in lathel cell injury due to ischemic myocardium .The left atrial appendage was snared and the left circum -flex coronary artery was isolated .

c. Increase acidosis:Acidosis activate cardiac myocote death through Bcl-2 protein .Coronary artery leads to injury and loss of myocardial tissue by deprivation of blood flow.