which type of chemical bond is most likely formed when a tox

which type of chemical bond is most likely formed when a toxicant permanently binds to a ligand substrate?

Solution

High -affinity irreversible covalent bonding formed when a toxicant (cyanide) permanently binds to a ligand substrate (hemoglobin) result complete displacement of actual ligand finally changes the stereochemical aspects of \"substrate\". These events are leading changes in physiological alterations of the tissue systems to gain adequate actual ligand (for example, oxygen) finally result in immediate irreversible cell death

For example, toxicant, potassium cyanide is going to potentially uncouple the cytochrome c oxidase via \"formation of irreversible covalent bonding\" followed by complete affinity towards electron transport complex systems and nearly inhibit oxygen consumption within the suspension of respiring mitochondria. 1 mM potassium cyanide, nearly abolish 98% inhibition of oxygen consumption.

Cyanide potentially inhibit terminal electron (proton) transport to oxygen thereby CN- produces hydrogen cyanide followed by 0 ATP formations