Why would it make sense that mitochondria would be resistant

Why would it make sense that mitochondria would be resistant to autophagy?

Solution

Autophagy refers to a biological process in which a cell hydrolyzes its ingredients and consequently the whole cell under the molecular signalling stimuli and stress. During autophagy, the hydrolytic enzymes of the cell are released from the lysosomes which slowly degrade the whole cell. Most of the organelles are prone to this hydrolytic digestion and hence autophagy while mitochondria show some extent of resistance to it. This can be attributed to following reasons:

Hence, owing to above given explanation and reasons, it makes sense that mitochondria are very resistant to autophagy and mitophagy indeed leads to cell death.