Lactate dehydrogenase has a 1000 fold selectivity for lactat

Lactate dehydrogenase has a 1000 fold selectivity for lactate as a substrate over malate. However, if a mutation occurs that alters an active site glutamine residue to an arginine residue, the enzyme shows a 10.000-fold selectivity for malate over lactate. Explain this astonishing transformation.

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