Homework Soursewhat difference in the regions of sirt1 and sirt2 genes in p
what difference in the regions of sirt1 and sirt2 genes in people addicted to cocaine increases their expression?
what difference in the regions of sirt1 and sirt2 genes in people addicted to cocaine increases their expression?
what difference in the regions of sirt1 and sirt2 genes in people addicted to cocaine increases their expression?
Solution
Sirf genes code for sitrulins which are the mediators of plasticity at the molecular and cellular levels. They act at the NAc i.e. nucleus accumbens region of brain. The administration of coccain increases the expression of SIRT1 and SIRT2 because it alters the activity of the transcription factor FosB leading to the modifications of histones of these genes.
