How does H pylori work in attacking the stomach lining What

How does H. pylori work in attacking the stomach lining? What drugs are available for preventing ulcers caused by this bacteria?

Solution

H.pyroli means helicobacter pylori.it is a gram negative bacteria. it belongs to the family of helicobactereace. It is decided in two subgroups. First is gastric helecobacter species and anthor is enterohepatic species. Gastric helecobacter pyroli is responsible for producing ulcer in stomach. Gastric helecobacter species adapted to the inhospitable condition found to be on upper line of gastric mucosa,and it is thought that stomach of all the mamalia can be colonized by the genas of h.pylori. all h.pylori are urase positive and highly mobile by means of flegella. Urase are responsible for the short time survival in the gastric acidic media where the rapid motility due to flegella towards the more neutral pH. This two prime factor responsible for the adoption of h.pylori in to gastric environment.once it enters in to the nature pH region means liner of tissue than it creates colonization, which is responsible for the rapid growth in tissue. The motility is the chemotactic towards the bicarbonate. Spiral morphology and flegella are responsible for the penetration of bacteria inside the mucous membranes. Urase is responsible for the production of ammonia and nutrition absorption from the body by Collony leads to formation of ulcer.

The drugs available to treat ulcer produce by h. Pylori is the 7 day regimen of amoxicillin, clarithromycin,lancoprazol. The second line therapy include amoxicillin, lancoprazole,levofloxacin. 10 to 14 days regimen include omeprazole, amoxicillin and clarithromycin for 10 days. 14 days include Bismuth subsalicylate, metronidazole and tetracycline. If the persistent H. Pylori infection is there than 7 days regimen of 400 mg moxifloxacin qd, 1000mg amoxicillin bid, and 20 mg esmoprazol bid is used. Although resistance strain required more effort to traet. In such case nitroimidazole containing derivative are mostly used.