O scoA O CoAS SCoA HO Co 2 CoASH 20 ou SolutionThe reacti

O /\\/ scoA O + CoAS/ SCoA HO +Co, + 2 CoASH 20 ou

Solution

The reaction proceeds with the following steps ( Please note, these are general steps of fatty acid synthesis)

1. Transfer of the malonyl group of malonyl-CoA to ACP catalyzed by malonyl-CoA-ACP transacylase.

2. Addition of an acetyl group from malonyl-ACP between the thioester bond of the acetyl-ACP molecule in reaction 1

3. Reduction of the Beta-keto group to a Beta-hydroxyl group with NADPH catalyzed by Beta-keto-ACP reductase.

4. Dehydration between the alpha and Beta carbons , catalyzed by Beta-hydroxyacyl-ACP dehydrase).

5. The acetyl group of reaction 1 is replaced by the growing acyl-ACP molecule