Homework SourseReview the following chart and answer the following question
Review the following chart and answer the following questions: 1. Based on LD10, which toxicant is more potent? Why? 2. Based on LD50, which toxicant is more potent? Why? 3. At what dose do these toxicants have the same percentage lethality?
Toxicology Chart
Dose
Toxicant A
Toxicant B
mg/kg
% lethality
% lethality
0.01
20
25
0.05
25
30
0.1
30
35
0.5
40
40
1
45
50
5
55
65
10
60
70
50
70
85
100
75
95
500
95
105
1,000
100
107
5,000
105
108
10,000
107
109
| Dose | Toxicant A | Toxicant B |
| mg/kg | % lethality | % lethality |
| 0.01 | 20 | 25 |
| 0.05 | 25 | 30 |
| 0.1 | 30 | 35 |
| 0.5 | 40 | 40 |
| 1 | 45 | 50 |
| 5 | 55 | 65 |
| 10 | 60 | 70 |
| 50 | 70 | 85 |
| 100 | 75 | 95 |
| 500 | 95 | 105 |
| 1,000 | 100 | 107 |
| 5,000 | 105 | 108 |
| 10,000 | 107 | 109 |
Solution
Based on the chart toxicant B is more potent in LD 10 because it can kill higher percentage of cell and toxicant A
is more potent in LD 50 because toxicant A shows a lesser harmful effects on cell and in 0.5mg/kg dose shows a Same percentage of lethality.
