Type II diabetes leads to an in blood glucose due to an in G

Type II diabetes leads to a(n) in blood glucose due to a(n) in GLUT4 activity in target cells in response to insulin. decrease, increase increase, increase decrease, decrease increase, decrease

Solution

Type II diabtes leads to increase in blood glucose due to decrease in GLUT4 activity in traget cells in response to insulin.

The major cellular mechanism for disposal of an exogenous glucose load is insulin-stimulated glucose transport into skeletal muscle.Skeletal muscle both stores glucose as glycogen and oxidizes it to produce energy following the transport step.The principal glucose transporter protein that mediates this uptake is GLUT4 of a family of sugar transporter proteins containing 12-transmembrane domains.The GLUT4 glucose transporter is a major mediator of glucose removal from the circulation and a key regulator of whole-body glucose homeostasis.So decrease in GLUT 4 action leads to increase in blood sugar levels which is further a cause for type II diabetes.