Starting out with glucose fatty acids and other required bio

Starting out with glucose, fatty acids, and other required biomolecules, present a strategy for synthesizing phosphatidyl ethanolamine?

Solution

Phosphatidylcholine (PC) and Phosphatidylethanolamine (PE) are two of the major lipids found in the cell mebrane and account for more than 50% of the total lipids in the cell. The production of PE from glucose and fatty acids can be summarized as below -

1. Glucose is converted into acetyl CoA via the glycolysis pathway.
2. Acetyl CoA can either be used for the production of fatty acids, or for ATP. The balance equation depends upon the body\'d requirment for ATP. It also depends upon the type of cell in which the reaction takes place.
3. The presence of cytosolic enzymes and acyl carrier proteins (ACP) convert the acetyl CoA into long chain fatty acids.
4. In some cases, the the Acetly CoA is used for the production of diacylglycerol.
5. Simultaneously, the amino acid serine undergoes decarboxylation to form ethanolamine.
6. This is followed by phosphorylation of ethanolamine by the cytosolic enzyme ethanolamine kinase, followed by reaction of the product with cytidine triphosphate (CTP) to form cytidine diphosphoethanolamine
7. Finally, the enzyme CDP-ethanolamine:diacylglycerol ethanolaminephosphotransferasecatalyses the reaction of the last compound with diacylglycerol to form phosphatidylethanolamine.