Cystic fibrosis is caused by mutations in the CF gene and th

Cystic fibrosis is caused by mutations in the CF gene, and there are several different mutations that are known to result in CF disease. The CF mutations behave as recessive alleles to the WT CF allele. If two carriers that have different mutations in their CF genes have children what is the probability that one of their children will have CF disease?

A. 25%

B. 50%

C. 100%

D. 75%

Solution

A. 25%

cystic fibrosis is due to mutation in the CFTR gene th on the chromosome number 7. As many as 700 mutations are recognised in the gene but the inheritance can happen either in homozygous condition or hetreozygous condition.