Prior to the development of antiretroviral drugs HIV infecte

Prior to the development of anti-retroviral drugs, HIV infected patients with AIDS developed a high frequency of Kaposi’s sarcoma. Why?

a. Compromised Immune surveillance promotes the spontaneous appearance of Kaposi’s sarcoma.

b. High levels of HIV replication in AIDS patients cause Kaposi’s sarcoma.

c. Latent EBV is reactivated and causes Kaposi’s sarcoma.

d. Latent HHV-8 is reactivated and causes Kaposi’s sarcoma.

Solution

Kaposi\'s sarcoma (KS) is a tmors with tiny new blood vessels grow under the the skin and in membranes of your mouth, nostril, eyes, and anus. It can spread in lungs, liver, stomach, intestines, and lymph nodes, which are glands that help fight contamination.

The failure of a tumor to develop as it does within the immunosuppressive host might be not due to a loss of tumor-cell killing within the suppressed host. Instead, the better degree of immune response , even to tumor-inhibitory ranges, probably offers less fine guide to tumor increase.

Because humans with HIV have weakened immune systems, they may be much more likely to expand KS. Most severe instances happen when a person has AIDS, the HIV contamination, however skin lesions can also show up in advance. They\'re a signal for high immune system

Both EBV and KSHV are latent residents in B lymphocytes and display sporadic reactivation in lymphoepithelial tissues including tonsils .Lytic reactivation of EBV or KSHV in epithelial cells of the nasopharynx is strongly inspired by the differentiation. In addition, XBP-1s, a made from the gene accountable for B cellular differentiation, turned into currently suggested to be one of the physiological stimuli that trigger the lytic switch of EBV and KSHV in latently infected B cells.With the aid of infection with human herpesvirus eight (HHV8), also known as Kaposi sarcoma-related herpesvirus (KSHV) or KS agent