What is an outcome of p53 and Rb inactivation by tumor virus

What is an outcome of p53 and Rb inactivation by tumor viruses?

a. Their inhibition permits infected cells to bypass eliminating immune responses, thereby promoting cell survival.

b. Their inhibition increases proliferation of mutated cells and spread of virus that can transform neighboring cells.

c. Their inhibition permits DNA mutations to be passed on to proliferating cells.

Solution

Answer : The correct answer is B (Their inhibition increases proliferation of mutated cells and spread of virus that can transform neighboring cells)

Explanation : Both P53 and Rb are the tumor suppressor genes which acts as cellular brakes for the proliferation of infected/mutated cells. Inhibiting the expression of these genes allows uncontrollable proliferation of cells.