Inhibiting the sodiumglucose symport SGLT2 is expected to ca

Inhibiting the sodium-glucose symport SGLT2 is expected to cause a(n) __________________________ in the osmolarity of the tubular filtrate, and would thus _____________________ the risk of dehydration.

Solution

Inhibiting the sodium-glucose symport SGLT2 is expected to cause a(n) increase in the osmolarity of the tubular filtrate, and would thus increase the risk of dehydration.

Explanation:

SGLT2 inhibitors occlude SGLT2 glucose reabsorption pathway and cause glycosuria, thereby reducing plasma glucose concentrations. They reduce renal glucose reabsorption, and increase urinary glucose elimination (increased osmolarity), thus lowering glucose blood levels.