how has the knowledge of human genome allowed a level of evo

how has the knowledge of human genome allowed a level of evolutionary analysis? please elaborate with a paragraph

Solution

human genome is perfect complete set of nucleic acid sequence for human [Homo sapiens] it encoded DNA in cell nuclei and in individual mitochondria DNA molecule Human genomes includes protein-coding DNA genes and non-coding DNA. Human genome will improve the development of new branch of science called evolutionary genomics. Computational analyses of human genome reveal the number of genes or repetitive elements or gene duplication or compositional heterogeneity in human genome. There are number of factor in human genome which allowed as understanding the level of evolutionary analysis.

1.Repetitive elements in proteins- repetitive element, like insertion into genome result in deleterious and unlikely to survive, too many translate repetitive element are found in proteins.Alternet splicing- in alternate splicing one gene can be translated into multiple protein example- isoenzymes in different organs of human

2. Domain sharing & conservation-domain is structural and functional unit in protein. investigate the frequency of domain sharing , the same domain appears in different proteins, generally we use InterPro domain database.Domain sharing & order conservation within human & between human or other eukaryotes

3.Duplicate genes- 2 genes that derive from gene duplication are called paralogous

Orthologous- if they were derived from same gene by speciation.

Comparatively genomics studies suggest that the approx 5% of human genome are conserved through evolution over 200 million years ago. Chimpanzee genome are differs from the human genome only by 1.23% by comparisons of direct sequence

After the completion of human genome project we can use bio-tools to better understand analysis evolutional of human genome,

There are many tools- epigenetics, bioinformatics, ecological genomics, next-generation sequencing, evolutionary genomics, genomic analyses, 26s r-RNA in nuclei’s or mitochondria