What 2 chemicalsproteins do PRIMARY tumor cells secreteSolut

What 2 chemicals/proteins do PRIMARY tumor cells secrete?

Solution

Answer:

Angiogenesis, defined as the formation of new blood vessels from pre-existing ones, is a key process in normal development and pathological conditions such as cancer. The proven role for angiogenesis in providing oxygen and nutrients necessary for tumor growth explains its clinical relevance and therapeutic potential.

The angiogenic factors secreted by primary tumor cells for angiogenesis to occur are:

1. Vascular endothelial growth factor (VEGF)

2. Fibroblast growth factors (FGFs)

3. Platelet-derived growth factor (PDGF)

4. Hypoxia inducible factor 1-alpha (HIF1-alpha): regulates VEGF