Which of the antiHIV drugs would be least effective in a PrE

Which of the anti-HIV drugs would be least effective in a PrEP cocktail? Protease Inhibitors Fusion Inhibitors NRTls NNRTIs Integrase Inhibitors What is the effect of release of histamine that helps leukocytes access a site of damage? Which is not likely to cause a gout flare-up? diuretic prescribed for high blood pressure dehydration from stomach flu going outside barefoot in cold weather eating lots of liver weight loss

Solution

The third option NRTis inhibitors are least effective combinations. NRTis are nucleotide/ nucleoside analogue reverse transcriptase inhibitor which are found that leas effective as they can check the disease one in billion.

Most of the histamines are found in mast cells and leucocytes in form of granules. During infection the IgE antibodies binding occur in mast cells, which release the histamines. The leucocytes have G protein-coupled histamine receptors which help to produce antibodies, secrete the inflammatory response triggers (heparin and histamine), and the histamine neutralization. These are important in inflammatory process.

The option 5^th is true, overweight condition make gout flare up; but weight loss reduces uric acid level in body which helps in decreasing the risk of gout.