Speculate on what would happen to the resting membrane poten

Speculate on what would happen to the resting membrane potential (RMP) of a cell if the ECF concentration of K⁺ was 3 mM rather than the normal value. Assume all other ion concentrations are normal and the cell has normal permeability to Na⁺, K⁺, and Cl^-. Do not calculate the membrane potential, but rather identify how RMP would change and justify your answer by explaining changes to gradients and resting ion fluxes. (3 points)

Solution

Answer:

The concentration of the ions in the extracellular fluid (ECF )and intracellular fluid (ICF) varies. Resting potential is developed due to the movement of the N+ and K+ across the membrane. The movement of ions require ATP as it is active transport, and movement of the ions takes place from lower concentration to higher concentration.

In Extrcellular fluid, the concentration is,

K+ = 3 mM

Na+ = 142mM

Ca+2 = 5mM

Cl- = 103mM.

The concentration of the intracellular fluid is,

K+ = 148 mM

Na+ = 10mM

Ca+2 = less than 1 mM

Cl- = 4 mM.

The concentration of Potassium is higher in the ICF, than compared to ECF.

The normal value of ECF is 5mM, but according to given, the concentration is 3mM,

Due to less concentration of the potassium in ECF leads to Hypokalemia,which causes,hyperpolarization (Inhibits action potential.). Efflux of the potassium and influx of the chlorine ions takes place, which is called as a hyperpolarization.Due to hyperpolarization, the improper electric conduction of heart will take place.