Most human genetic disorders are due to autosomal recessive

Most human genetic disorders are due to autosomal recessive inheritance. Describe how an individual can acquire these conditions from parents that do not display symptoms. A man has an X-linked recessive form of pattern baldness. From which parent did he inherit this condition. Explain your answer. Sickle cell disease in an inherited human condition of the blood cells. Those who receive the allele from both parents (homozygous) has a fill blown sickle cell disease. A person who only has one copy of the allele (heterozygous) may experiences sickling of their blood cells under certain, stressful conditions. Give a simple explanation for the heterozygous individual having a mild form of the disease. Why do individuals who inherit an A type allele and a B type allele have blood type AB while a person who inherits an A type allele and an O type allele have blood type A? How are pedigrees useful in counseling couples regarding the likelihood they can pass a genetic disorder on to their offspring? A female child has the autosomal dominant condition of Polydactyly. The mother has the normal number of fingers and toes while the father has six fingers on each hand. The couple has a second child, a boy, who has the normal number of fingers and toes. Give the genotype of each parent and each child. Parent #1_______ Child #1 ________ Parent #2 _______ Child #2 ________ Draw a pedigree demonstrating Polydactyly in the above family. What is the likely hood that if they have a third child they will be born with Polydactyly?

Solution

1.An indivisual can aquire autosomal recessive disorder when there are two copies of an abnormal gene which should be present in a person so that it can move into generations.

2.This is inherited from the female mother because the female has both the X,X which can be inherited by male.

3.In people sufferiing from the heterozygous sickle cell disease,these allele usually produce both normal and abnormal hemoglobin This means there are two alleles which are usually codominant with respect to the actual concentration of hemoglobin that is present in the circulating cell.

4.This is because AB blood type has both A AND B ALLELES while A blood type has only A or O alleles.It does not include the B allele.