1You are an animal composed of segments like an earthworm wa

(1)You are an animal composed of segments, like an earthworm, wasp, or centipede. Your segments are not visible until you remove your skin and look at the muscles of your torso as well as your vertebrae and ribs. Your muscles develop in blocks called somites from your head(anterior) to your tailbone(posterior). Protein signals from the head interact with receptors in cells further down to control the number and size of your somites. One of these signals is delta it binds the receptor Notch. When Delta folds its fold contains units of secondary structure that are repeated, each unit folding on its own. These repeats are called EGF-like repeats. In the final fold these units stack together to make a solenoid shape (a hollow spiraled tube somewhat like a short or partial helix). Which of the following terms are appropriate to describe a single EGF repeat in the chain? Pick ALL that apply. there is more than one answer.

super secondary structure

secondary structure

quarternary structure

a structure found in the center of a protein folding funnel

tertiary structure

domain

a structure found at the bottom of a protein folding funnel

a structure found at the top of a protein folding funnel

Solution

Answer: F. domain; b. secondary structure; H. a structure found at the top of a protein folding funnel

Reason:

Epidermal growth fcaror is “extracellular domain made of protein of secondary structure in which beta-helices are prominent. So that, it is a membrane ebound protein that is to be secrete with a structure found at the top of a protein folding funnel

Amplification and receptor docking research on the tyrosine kinase activity for example quantitative structure activity relationship (QSAR) of the epidermal growth factor receptor enable in finding novel therapies against the tumor metastasis. Constitutive mutation in the epidermal growth factor receptor may leading to stimulation of the phosphoionitidyl – kinases and further produces downstream effects that activate tumor cell division.