Clomid is another infertility medication that is commonly us

Clomid is another infertility medication that is commonly used, often taken from day S of the menstrual cycle to day 9. Clomid binds estrogen receptors of the pituitary gland without activating them. What is the effect of this medication on the pituitary gland? Given this, what happens now in the ovaries? Be sure you explain how this female\'s hormones would be different both before and after ovulation. Include in your explanation why this medication might be associated with twins or triplets. Yes, you can answer this without doing more research.

Solution

Clomifene also known as Clomid is an infertility medication. It is a synthetic non stroidal drug. This drug acts by stimulating the ovary to release egg. This drug acts by upregulation of hypothalamic-pituitary-gonadal axis. Thisbecomes possible by binding of estrogen receptorsin the hypothalamus inhibiting negative feedback of estrogen on gonadotrophin release.

In normal female hormonal cycling, high levels of estrogen and progesterone produced from the corpus luteum inhibit GnRH, FSH and LH at the hypothalamus and anterior pituitary 7 days past ovulation. If fertilization does not occur, the corpus luteum disintegrates due to a lack of beta-hCG and is excreted out in the form of menstrual flow. Clomefene is typically prescribed beginning on day 5 and continuing for 5 days. By that time, FSH level is rising steadily, causing development of a few follicles. Follicles in turn produce the estrogen, which circulates in serum. In the presence of clomifene, the body perceives a low level of estrogen, similar to day 22 in the previous cycle. Since estrogen can no longer effectively exert negative feedback on the hypothalamus, GnRH secretion becomes more rapidly pulsatile, which results in increased pituitary gonadotropin (FSH, LH) release.Increased FSH level causes growth of more ovarian follicles, and subsequently rupture of follicles resulting in ovulation. Ovulation occurs most often 6–7 days after a course of clomifene.

Clomifene is generally prescribed to women having poly cycstic ovary disease. In this condition mutiple eggs are formed as cysts and are unable to get released. Clomifene releases these eggs simultaneously and thse eggs fertilized which results in twins or triplets.