A randomised placebocontrolled crossover study was performed

A randomised, placebo-controlled cross-over study was performed to examine the effect of pronethalol treatment on angina pectoris (heart related chest pain). Each patient received pronethalol treatment for four weeks and placebo treatment for four weeks with non-overlapping treatment periods with treatments administrated in random order. The table below shows the number of angina pectoris attacks for each patient during their treatment periods. What test can be used to test whether treatment affects angina pectoris? Substantiate your answer. Perform the test in a) at the 5% significance level. Interpret your result. Find a 95% confidence interval for the proportion of patients benefitting from pronethalol treatment.

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