Many enzymatic reactions in metabolic pathways are at or nea

Many enzymatic reactions in metabolic pathways are at or near equilibrium. Why is this (4pts)?

Solution

1. because of large excess of catalytic capacity compared to the flux through the enzyme loci.

2.the ratio of enzyme flux to steady state flux through the overall pathway is high.

3.overall flux through the enzyme locus as well as on the kinetic parameters of the other enzymes in the pathway contribute to equilibrium

4..Some metabolic pathways flow in a \'cycle\' wherein each component of the cycle is a substrate for the subsequent reaction in the cycle, such as in the Krebs Cycle