Dianas Death Unraveled Hemophilia causes a lack of blood clo

Diana’s Death Unraveled

Hemophilia causes a lack of blood clotting, but Diana died from overactive blood clotting. Factor V Leiden is the most common hereditary hypercoagulability disorder amongst Eurasians. About 5% of Caucasians in North America are affected, and it is inherited as an autosomal dominant mutation that causes high levels of clotting Factor V. It can cause deep vein thrombosis (blood clot in the vein), pain, life-threatening strokes, and heart attacks.

A) Based on the types of mutations we’ve discussed so far in class, which does Factor V Leiden fall into?

B) There is enough research evidence to support phenotypic changes in hemophiliacs with Factor V Leiden mutations. Based on what we’ve discussed in chapter 4, what are some suggestions as to why this might happen? Be sure to describe the normal symptoms of hemophilia and how protein levels are affected to support your answer.

Solution

A) There are certain individuals who have a DNA mutation in the gene used to make a factr V protein.These individuals are said to have the factor V leiden gene mutation.Individuals with Factor V leiden mutaions have inherited thrombophilia.