Below you will find a series of events that take place durin

Below you will find a series of events that take place during apoptosis. Develop a hypothesis about the series of events after the induction of apoptosis. Give the evidence that leads you to hypothesize as such. To indicate the order, you can simply indicate the letter for the appropriate event. Place the events in their proper order (from first to last). New order of events Events A. DNA fragmentation B. Increase in Caspase 3 activity C. Chromatic Condensation D. PARP cleavage E. Cytochrome C release 1. _____ 2. _____ 3. _____ 4. _____ 5. _____

Solution

Answer:

1. E

(Upon induction, cytochrome c is released from the mitochondria)

2. B

(Cytochrome c induces the activation of caspases, including caspase 3 downstream of the cascade)

3. D

(Caspase 3 activates PARP)

4. C

(The penultimate stage is chromatin condensation)

5. A

(Chromatin condensation is followed by DNA fragmentation)