One late night in the late mystery drug X spills directly on

One late night in the late, mystery drug X spills directly onto the mouse cage. The next time you draw blood from these mice the test results show a complete absence of IgE, IgA, and IgD. What immune process is impeded to create this defect and what impact will the loss of these antibodies on the mouse\'s immune system?

Solution

IMMUNOGLOBULINS E, A, AND D are formed in humoral antibody mediated immune respnse after proper MHC recognition by antigen presenting cells, In this case if immunoglobulins are missing it meand somehow antigen presentation mechanism by MHC CLASS 2 has got defung or some other step which produces mature antibody producing Bcells has got defung, since IMMUNOGLOBULIN A AND M are present there from begigning and arepart of innate immunity thus it means that the organism wont be able to start antigen specific antibody production hence secondary immune responses would be lost and the organism will be succeptible to diseases caused by invading pathogens which can evade innate body immunity.

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