Do you think histones would use an alpha helixmajor groove m

Do you think histones would use an alpha helix-major groove mechanism of DNA binding? Why or why not?

Solution

Chromosomes contain DNA (deoxyribonucleic acid) bound proteins called “histones,” which serve to “package” the DNA and there by controls its functions. Histones would use an alpha helix major groove mechanism of DNA binding via globular domain that form a winged helix motif. The basic amino acids present in histones are lysine and arginine that impart positive charge to their structure at cellular pH. The histone fold is associated with 70 amino acids containing protein in 3 alpha helices with helix-loop-helix to bind around DNA in head-to-tail intermediates to produce stability to DNA

These histone proteins are specific to the each cell type or DNA type, not all cell types have the DNA for all histone variants. Chromsomes possess two chromatids with a central centromere. These chromosomes are mainly divided into monocentric, acentric and dicentric chromosomes