Genomewide association studies rely on the principle that ma

Genome-wide association studies rely on the principle that markers that are closer on the chromosome to a causal variant will tend to show stronger statistical associations with the corresponding phenotype. Briefly explain why the physical proximity of the marker has this effect.

Solution

Genome-wide association: Genome wide association study also known as whole genome association study.

Genetic marker: Genetic marker is a gene or DNA sequence with a known location on a chromosome that an be used to identify Species.Genetic markers are used to study the relationship between an inherited disease and its genetic cause.commonly used types of genetic markers are

Genomic wide association studies compares the DNA varying phenotypes.SNPs are used as genetic marker in genome wide association studies also.exact number of SNPs depends on the genotype technology are typically one million or more.The physical proximity of the marker has this effect because YAC yeast artificial chromosomes contig from chromosomes contains 43 clones and 19 sequence-tagged sites. Among the 19 STSs are eight corresponding to microsatellite-type genetic markers, including seven (CA)n repeat-type Genethon markers that shows stronger statistical associations with the corresponding phenotype.