The participation of nitric oxide in signal transduction Que

The participation of nitric oxide in signal transduction Question 25 options: A. depends upon interaction with a heterotrimeric guanine nucleotide-binding protein. B. is mediated by a receptor localized in the nucleus. C. requires the oxidation of lysine by nitric oxide synthase. D. results in the activation of guanylyl cyclase.

Solution

D. results in the activation of guanylyl cyclase.

Explination

NO, is a reactive free radical, which diffuses into the smooth muscle cells of the blood vessel and interacts with soluble form of guanylate cyclase. Stimulating the soluble guanylate cyclase to generate the second messenger cyclic GMP..

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