For a neurotransmitter like ACH or glutamate what factors de

For a neurotransmitter like ACH or glutamate, what factors determine affinity of its binding to its receptors?

Solution

Neurotransmitters binding may effect the postsynaptic neuron, this neuron might be connected to many neurons. If the total of excitatory influences are higher than inhibitory influences, the neuron will fire, it will be helpful to release neurotransmitters and pass the information to the neighboring neurons.

ACh is known as Acetylcholine, it is the first known neurotransmitter, here, metabotropic receptors are Muscarinic acetylcholine receptors and Ionotropic receptors are Nicotinic acetylcholine receptors. The ACh exerts its effects by binding and by activating receptors located on the surface of cells.The ACh molecules also bind to receptors of nicotinic ion-channel on the muscle cell membrane. It also binds to postsynaptic receptors, this binding helps ion channels to open and it allows sodium ions to flow into the muscle cells.

Glutamate is the prominet transmitter, it is very active, it contains 90% of the synapses in the human brain, etabotropic receptors are Metabotropic glutamate receptors and ionotropic receptors are NMDA receptors and kainate receptors in glutamate. Excessive glutamate can cause cell death resulting in seizures or strokes. Opposing postsynaptic cell and receptors of glutamate bind and will be activated.