Describe in five sentences how the TLR system is used to fig

Describe in five sentences how the TLR system is used to fight HSV-1 encephalitis.

Solution

Toll like receptors are one type of PRRs, which are associate in the recognition of pathogen, associated molecular patterns. These receptors are initially identified in Drosophila, they are also found in macrophages, mast cells, dendritic cells in mammals. Toll-like receptors trigger the production and release of cytokines and also activate other host defense responses associated with innate and adaptive immune response. In response to HSV -1 (herpes simplex virus 1), the TLR-2 releases cytokines that cause severe inflammatory response (innate immune response), which leads to encephalitis. Antagonism of these receptors is likely to provide protection against encephalitis caused by HSV-1. The TLR-2 are mainly located on the surface of microglia and astrocytes.