You are investigating a cancer cell line cells that were ini

You are investigating a cancer cell line (cells that were initially isolated from a patient\'s tumor and grown in culture in the lab) to determine what oncogene is driving their growth. you determine that the cells have a constantly high level active MAP kinase. However, Ras is not mutated and is not active in these cells. based on what you know about growth factor signaling, what proteins to you suspect might be mutated to be constantly active in these cells?

Solution

The signal proteins which are called as growth factors might be mutated and be active along with the Raf protein which multiplies occasionally even when Raf protein doesnt multiply.