Chlamydia infection causes fragmentation of the Golgi appara

Chlamydia infection causes fragmentation of the Golgi apparatus in an infected cell. Compare the microscope images of the Golgi apparatus in an uninfected (normal) and infected (with Chlamydia) cell above. Describe the differences you can observe in the structure. Based on your answer to part a, predict what problems or abnormalities you might expect to see in a Chlamydia-infected cell compared to a normal uninfected cell.

Solution

The uninfected image showing the typical normal ribbon like structure of the Golgi apparatus, some marker protein has been used to track the Golgi apparatus. When the infection proceeded the signal expanded indicating the dispersion of the labelled structure means disassembly of Golgi ribbon structure. The cell synthesize a huge amount of variety of macromolecules. The main function of the Golgi apparatus is to modify, sort and package the macromolecules that are synthesized by the cells for secretion purposes or for use within the cell. They are also involved in the transport of lipid molecules around the cell. so if disassembly of Golgi occur it wil disturb the secretion of these product and it will lead to accumulation of macromolecule in case of Chlamydia infection Intracellular pathogen morphologically and functionally manipulates a host Golgi apparatus to enhance lipid acquisition and secure its replication and development