Given the substrate below design an active site that may acc

Given the substrate below, design an active site that may accommodate and be specific for this ligand. OH -203P NHat

Solution

Depending upon what is the reactive site the ligand the active site can be of various types.

If the reactive site is towards the -OH and -NH₃⁺
Benzyl group be accommodated to hold the ligand through - (pie-pie) or - (pie-sigma) interaction at active site.

If the benzyl group is the reactive side
The -OH and -NH₃⁺ can be accommodated towards the active site through H bonding.

To exactly provide the design of the active site, you need to offer more information like if you are talking about protein/ enzyme active site or a chemical compound/catalyst. And also what part of the ligand you want embedded and what is the reactive portion.