Know protein structure levels The primary structure determin

Know protein structure levels. The primary structure determined the other three levels, binding to other molecule depends on its three-dimensional structure. What kind of interaction make the stable wrapping of one helix around another? Protein structure is determined solely by a protein\'s amino acid sequence. Should a genetically engineered protein in which the original order of all amino acids is reversed have the same structure as the original protein? Why? What are the function of molecular chaperones? Why can protein phosphorylation serve exclusively as a mechanism to increase enzyme activity?

Solution

Primary structure of proteins is a linear sequences of amino acids and stable interaction between of one helix around another is Hydrogen bonding

Genetically engineered protein in which the all amino acids is reversed have the same structure as the original protein because of construction of promoter

Function of Molecular Chaperones or heat shock proteins:

1.These are essential proteins induce misfolded proteins to refold to their native conformations

2. It is increase rate of protein synthesis at elevated temperatures

Role of Protein phosphorylation:

1. It is an important regulatory mechanism that occurs in prokaryotics and eukaryotic organisms

2. Kinase phosphorylate proteins which results in increases rate of transcription leads to increase enzyme activity

3. Many enzymes or receptors are switched on or off by phosphorylation and dephosphorylation

4. It is important for protein-protein interaction eg: phosphorylation of cystolic components of NADPH oxidase