How are DNA mutations called that cause a mutation in the am

How are DNA mutations called that cause a mutation in the amino acid sequence, where the original and the mutated amino acids have very similar properties? Give three examples for such mutations on the amino acid level.

Solution

Answer: This type of Mutation is called Silent mutation. Silent mutation does not significantly alter the phenotype of the organism.

Two categories of Silent mutation are there:

A. Base changes in the DNA that do not cause any changes in the amino acid.

eg. GUU (Valine) to GUC (Valine)

B. Base changes in DNA that changes the amino acid with another amino acid having similar properties and the replacement does not affect its activities. (Your question comes under this category)

eg. GSTP gene at codon 105: GUU (Valine) to AUU (Isoleucine)

XRCC1 gene at codon 194: CGG (Arginine) to UGG (Tryptophan)

XPD gene at codon 751: AAG (Lysine) to CAG (Glutamine)