What would be the molecular mass of the TOTAL DNA in the tet
Solution
What would be the molecular mass of the TOTAL DNA in the tetrad corresponding to chromosome 1?
chromosome 1 represents about 9% of the total DNA in human cells, where it is the largest human non-sex (autosomic) chromosome.
Chromosome 1 consists of about 249 million nucleotide base pairs where the number of genes varies 5,078 to 4,474
Approximate Molecular weight of Nucleic Acids is calculated using a formula:
M.W. of dsDNA = (Number of nucleotides x 607.4) + 157.9
= (498 million x 607.4) +157.9
(NOTE 249 million x 2 because they are base pairs = 498 million nucleotides)
= 302485.2 x 106 +157.9
= 3 x 1011
This is for a Double Stranded DNA molecule.
The question is molecular mass of the TOTAL DNA in the tetrad corresponding to chromosome 1 so, the final value x 4 gives the answer = 12 x 1011
