The activity of which enzyme would be impacted by mutations

The activity of which enzyme would be impacted by mutations in the promoter region of a gene? RNA polymerase Topoisomerase DNA polymerase Helicase

Solution

Answer: RNA polymerase

Explanation:

The region of the gene upstream from the region to be transcribed contains specific DNA sequences that are essential for the binding of transcription factors and a region called the promoter, to which the RNA polymerase binds. These sequences must be a specific distance from the transcriptional start site for successful operation. If any mutations happened in promoter region that causes RNA polymerase activity.