Genomewide association studies rely on the principle that ma

Genome-wide association studies rely on the principle that markers that are closer on thechromosome to a causal variant will tend to show stronger statistical associations with thecorresponding phenotype. Briefly explain why the physical proximity of the marker hasthis effect.

Solution

Genome-wide association studies (GWAS) rely on the principle that genetic markers that are closer on the chromosome to a causal variant will tend to show “stronger statistical associations” with the corresponding phenotype. The physical proximity of the marker has associated with functional “single nucleotide polymorphism” that repeated short tandem genome units affecting the phenotype, often known as “quantitative trait locus”. Sometimes these stronger statistical associations are also associated due to dominance or recessive penetrance