Can Ci protein nuclear receptors beta catenin and the cytopl

Can Ci protein, nuclear receptors, beta catenin, and the cytoplasmic part of Notch ALL serve as transcriptional regulators?

Solution

Yes, your statement is correct. All these are transcriptional regulators.

Ci protein is an important transcription factor/regulator of the Hedgehog signaling pathway in Drosophila. This pathway is important for embryonic development.

Nuclear receptors are ligand activated transcription factors/regulators. They are present on nuclear surface. When a ligand enters the cell via diffusion, then it binds to nuclear receptors which further activate a transcription cascade.

Beta-catenin is also a transcriptional regulator and is important in Wnt signaling pathway. This protein is degraded in absence of Wnt signal. Beta-catenin decides cell fate during development, and is important in maintenance of pluripotency in cells.

Notch is a transcription factor and a part of Notch signaling pathway. It also decides cell fate during development.